Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population

Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population.

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide polymorphisms (SNPs) have been reported for the MDR1 gene. The effect of these polymorphisms on P-gp function or their clinical impact is in most cases unknown, but some of the SNPs are known to be of functional relevance and can also ...

Allele Frequencies and Genotype Frequencies

Association of Acute Lymphoblastic Leukemia and MDR1 Gene Polymorphism in an Ethnic Iranian Population

Background: The frequency of the multi-drug resistance 1 (MDR1) gene C3435T polymorphism differs in various ethnical populations such as Asian, African, and Caucasians populations. A silent C3435T polymorphism in exon 26 of MDR1 has been reported to be associated with a decreased expression of P-gp in TT genotypes carriers compared with CC genotypes carriers. Materials and Methods: To evaluate ...

Genotype and Allele Frequencies of MDR-1 Gene Polymorphism in Jordanian and Sudanese Populations

The aim of this study was to determine the genotype and allele frequencies of MDR1 gene C3435T polymorphism in Jordanian and Sudanese populations, and to compare them with the frequencies established in various ethnic groups. Genotyping was carried out on 116 unrelated Jordanian and 131 Sudanese subjects. The genotypes of polymorphic position C3435T were determined by PCR-RFLP assay. Results sh...

Frequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population.

The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as a gate-keeper against various kinds of xenobiotics. Several single nucleotide polymorphisms (SNPs) in the MDR1 gene that may influence PGP level and function have been identified. The aim of this study was to simultaneously analyze the three most important MDR1 SNPs, C3435T, G2677T/A and C1236T, in the Ser...